Yönetmen : Stephen Sommers Oyuncular : Brendan Fraser, Channing Tatum, Joseph Gordon-Levitt, Marlon Wayans, Sienna Miller Senaryo : Stuart Beattie, David Elliot Yapımcı : Stephen Sommers, Lorenzo Di Bonaventura

Bir önceki ortak çalışmaları transformers ile dünya çapında büyük bir gişe başarısı sağlayan Paramount Pictures ve Hasbro, yine olağan üstü bir macera-aksiyon filminde bir araya geldi.G.I. JOE ekibi, Mısır çöllerinden, kutup buzullarının altındaki sulara varana kadar her yerde en gelişmiş casusluk ve askeri ekipmanları kullanarak, yozlaşmış silah satıcısı Destro ile, gizemli Cobra örgütünün dünyayı kaosa sürüklemesine engel olmaya çalışıyor. Two soldiers stationed in Kazahkstan (Captain Duke Hauser and his partner "Ripcord") are ordered to transport special warheads created by MARS, an arms' manufacturer controlled by James McCullen. When they are attacked by thieves (led by Anastasia DeCobray, with whom Duke has history), they are saved by a top secret, international special forces unit known as "G.I. Joe". The leader of G.I. Joe, General Abernathy (or Hawk) is on the trail of the thieves: an evil organization called "Cobra". While Duke and Ripcord train to join the Joes, McCullen ("Destro") is secretly working for Cobra and plotting to recapture his metal-eating "Nanomite" warheads. Duke and Ripcord (with help from Heavy Duty, Snake Eyes, and the rest of the Joes) must prove that they are Real American Heroes -- by stopping the launch of these warheads before Cobra uses them to take over the world.