Biomedical Applications of Acridines [electronic resource] : Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases

Başlık
Biomedical Applications of Acridines [electronic resource] : Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases

ISBN
9783319639536

Yazar
Ježek, Jan. author.

Fiziksel Açıklamalar
XIII, 237 p. 79 illus., 25 illus. in color. online resource.

Dizi Bildirim
Progress in Drug Research, 72

Genel Not
Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.
 
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can  be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.

İçindekiler
Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.

Özet
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can  be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.

Konu Terimleri
Chemistry.
 
Neurochemistry.
 
Pharmacology.
 
Bioorganic chemistry.
 
Medicinal chemistry.
 
Nucleic acids.
 
Proteins.
 
Pharmacology/Toxicology.
 
Protein-Ligand Interactions.
 
Nucleic Acid Chemistry.

Ek Yazar
Hlaváček, Jan.
 
Šebestík, Jaroslav.

Ek Kurum Yazarı
SpringerLink (Online service)

Elektronik Erişim
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