Yönetmen : David R. Ellis, Lex Halaby Oyuncular : Samuel L. Jackson, Taylor Kitsch, Elsa Pataky, Julianna Margulies, Sunny Mabrey Senaryo : Sebastian Gutierrez, John Heffernan, David Dalessandro Yapımcı : Craig Berenson, Don Granger

Sean Jones, gangster Eddie Kim'in Los Angeles savcısını öldürdüğüne tanık olur. Sean'ın şahitlik etmesi, Kim'in hapse girmesine sebep olacaktır. Kim'in tek kurtuluşu Sean'ın duruşmaya gitmek için bindiği uçağa zehirli yılanlar koymaktır. While practicing motocross in Hawaii, Sean Jones witnesses the brutal murder of an important American prosecutor by the powerful mobster Eddie Kim. He is protected and persuaded by the FBI agent Neville Flynn to testify against Eddie in Los Angeles. They embark in the red-eye Flight 121 of Pacific Air, occupying the entire first-class. However, Eddie dispatches hundred of different species of snakes airborne with a time operated device in the luggage to release the snakes in the flight with the intent of crashing the plane. Neville and the passengers have to struggle with the snakes to survive.