Contents List of Contributors Preface Acknowledgements 1. Introduction-Stella Pelengaris and Mike Khan 2. The Burden of Cancer-William Steward and Anne Thomas 3. Nature and Nurture in Oncogenesis-Stella Pelengaris and Mike Khan 4. DNA Replication and the Cell Cycle-Stella Pelengaris and Mike Khan 5. Regulation of Growth: Growth Factors, Receptors and Signaling Pathways-Stella Pelengaris and Mike Khan 6. Oncogenes-Stella Pelengaris and Mike Khan 7. Tumour Suppressor Genes-Martine Roussel 8. Apoptosis-Stella Pelengaris and Mike Khan 9. Telomeres and Senescence-Maria Blasco and Mike Khan 10. Genetic Instability, Chromosomes and Repair-Stella Pelengaris and Mike Khan 11. Cancer is More Than a Genetic Condition-Stella Pelengaris and Mike Khan 12. Cell Adhesion, Cell-Cell Interactions and Metastases-Charles Streuli 13. Tumor Immunity and Immunotherapy-Cassian Yee 14. Angiogenesis-David Shima and Christiana Ruhrberg 15. Diagnosis of Cancer-William Steward and Anne Thomas 16. Treatment of Cancer: Chemotherapy and Radiotherapy-William Steward and Anne Thomas 17. Caring for the Cancer Patient-Nicky Rudd and Esther Waterhouse 18. Genomics and Proteomics in Cancer Research and Diagnosis-Bart de Witt Glossary Index